Atorvastatin pk
WebAug 12, 2024 · Atorvastatin helps to prevent cholesterol from building up in your arteries. Clogged arteries can block blood flow to your heart and brain. Atorvastatin may be used … Webunexplained muscle pain, tenderness, or weakness, especially if you also have a fever or feel more tired than usual while you take LIPITOR. muscle problems that do not go away …
Atorvastatin pk
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WebSep 13, 2024 · In this case, the PK model could be substituted by previous models published in literature, more specifically any of the models proposed by Faltaos et al. (2006) or Vargo et al. (2014) could be “plugged in” the multiscale computational framework in order to study the effect of atorvastatin. These features make this work suitable for ... WebApr 1, 2024 · Children 10 years of age and older with homozygous familial hypercholesterolemia (HoFH)—At first, 10 to 20 mg once a day. Your doctor may …
Therapy with lipid-altering agents should be only one component of multiple risk factor intervention in individuals at significantly increased risk for atherosclerotic vascular disease due to hypercholesterolemia. Drug therapy is recommended as an adjunct to diet when the response to a diet … See more In adult patients without clinically evident coronary heart disease, but with multiple risk factors for coronary heart disease such as age, smoking, hypertension, low HDL-C, or a family … See more Atorvastatin calcium tablets may be used with bile acid resins. The combination of HMG-CoA reductase inhibitors (statins) and fibrates should generally be used with caution [ see … See more The recommended starting dose of Atorvastatin calcium tablets is 10 or 20 mg once daily. Patients who require a large reduction in LDL-C (more than 45%) may be started at 40 mg once daily. The dosage range of … See more Renal disease does not affect the plasma concentrations nor LDL-C reduction of Atorvastatin calcium tablets; thus, dosage adjustment in patients with renal dysfunction is not necessary [ see Warnings and … See more WebDec 1, 2024 · Apparent oral clearance of atorvastatin in pediatric subjects appeared similar to that of adults when scaled allometrically by body weight as the body weight was the only significant covariate in atorvastatin …
WebNov 10, 2024 · The purpose of this study was to investigate the potential clinical relevance of estimating the apparent clearance (CL/F) of atorvastatin through population pharmacokinetic (PopPK) modeling with samples collected in a real-life setting in a cohort of ambulatory patients at risk of cardiovascular disease by using an opportunistic sampling … WebOct 26, 2016 · One non-compartmental PK study showed an effect of sex (11% decrease in area under the curve [AUC] in women) on atorvastatin disposition [11]. Moreover, population PK studies indicate a body ...
Web(PK-PD) relationships support the importance of studying factors affecting atorvastatin PK behavior to explain dif-ferential pharmacological responses. Atorvastatin is administered orally as a calcium salt of the active acid form with a clinical dosage ranging commonly from 10 to 80 mg/day. It is rapidly and well-
WebAtorvastatin is a carboxylic acid that exists in equilibrium with a lactone form in vivo. The purpose of this work was to assess gastric acid-mediated lactone equilibration of … the shoe company canada mississaugaWebSep 2, 2024 · National Center for Biotechnology Information my sse businessWebOct 6, 2024 · Currently available statins have important physicochemical and pharmacokinetic (PK) differences, which may explain their different potential for PK DDIs. 5, 11, 14 The statins are a class of amphiphilic drugs subdivided into lipophilic agents (ie atorvastatin, fluvastatin, lovastatin and simvastatin) that can enter directly in cells and ... my ssg solutionWebAug 22, 2008 · Parent-metabolite Population Pharmacokinetic (PK) Model for Atorvastatin and Its Metabolites: Atorvastatin Apparent Clearance (CL/F) [ Time Frame: Week 2, … my sse loginWebApr 12, 2024 · The present model revealed large interindividual variability in atorvastatin PK, notably during the absorption phase, known to be affected by multiple factors. First, food has been reported to decrease atorvastatin peak concentration (C max) and increase time to C max (T max) . Although all full PK samples were obtained under standardized ... the shoe company charlottetownWebOct 1, 2024 · Atorvastatin is a substrate of cytochrome P450 3a (CYP3a), organic anion-transporting polypeptides (OATPs), breast cancer–resistance protein (BCRP), and P-glycoprotein (P-gp). We aimed to develop a semiphysiologically based pharmacokinetic (semi-PBPK) model involving both enzyme and transporters for predicting the … my sse contactWebEthnicity plays a modulating role in atorvastatin pharmacokinetics (PK), with Asian patients reported to have higher exposure compared with Caucasians. Therefore, it is difficult to safely extrapolate atorvastatin PK data and models across ethnic groups. This work aims to develop a population PK model for atorvastatin and its pharmacologically ... my sse busness bills and payments