WebThe intense phosphorylation of p53- Ser 15, combined with activation of ATM and Chk2 (involving centrioles) as well as phosphorylation of H2AX seen in the untreated mitotic … WebOct 16, 2007 · Double-stranded DNA breaks induced by IR activate ATM by inducing autophosphorylation of the ATM kinase at Ser-1981 ( 14 ). The activated ATM kinase phosphorylates MDM2 at Ser-395 and p53 at Ser-15, the initial step of p53 activation in response to IR, which then leads to the stabilization of the p53 protein ( 15 ).
Declining p53 function in the aging process: A possible …
WebThe -p53 (Ser15) Assay is a sandwich immunoassay Phospho (Figure 1). MSD provides a plate that has been pre-coated with capture antibody for phospho-p53. WebOct 16, 2024 · Upon genotoxic stress, ATM can directly phosphorylate p53 at Ser15 52 - 54 and, in addition, mediates p53 Ser20 phosphorylation via activation of its direct substrate CHK2, which functions as a p53 Ser20 kinase. 55 Additionally, ATM was also reported as a p53 Ser46 kinase 50 (Figure 4 b). diamond clear products
Phosphorylation of p53 at either Ser15 or Ser46 residue is …
WebApr 29, 2004 · Indeed, doxorubicin-induced p53 phosphorylation on Ser15 residue in both MCF7 and MCF55a cells (Figures 3a, b and 5b), and this p53Ser15 phosphorylation was not affected by suppression of ERK2 or ... WebDec 1, 1999 · Mutation of these sites decreased p53-mediated and UV-induced apoptosis, and the reduction correlated with total abrogation of UV-induced phosphorylation on Ser37 and a significant decrease in Ser15 phosphorylation in mutant p53 containing alanine at Ser33 and Ser46. WebThere are various phosphorylation sites on p53, of which the phosphorylation at Ser15 is important for p53 activation and stabilization. p53 has been characterized to play a role in … diamond clear pool service