Tīmeklis2008. gada 1. apr. · The number of CD38 sites on Raji (98 108 ± 12 940; n = 5) was significantly higher than the number of CD31 sites on Jurkat J77 (5261 ± 474; n = 5). Assuming that translocation of CD38 on B cells and CD31 on T cells is driven by receptor-ligand interactions, the observed differences in surface expression of the 2 … Tīmeklismab induced both CDC and ADCC in vitro effectively, and there is a significant association between Daratumumab-induced CDC/ADCC and the expression level of CD38 in MM patients. Recently, Schutze et al. have generated a CD38-specific biparatopic heavy chain anti-bodies, which elicited CDC toward CD38-expressing mye-
ISB 1442, a first-in-class CD38 and CD47 bispecific antibody innate ...
Tīmeklis2008. gada 16. nov. · When the activities of SAR650984 and rituximab were directly compared in Daudi and Raji lymphoma cells that express similar levels of CD38 and CD20, SAR650984 had similar ADCC and CDC activities as rituximab, and, in addition, SAR650984 induced a greater percentage of lymphoma cells to undergo apoptosis … Tīmeklis2024. gada 5. nov. · In this study, we show that in a panel of 23 MM, AML and B-NHL cell lines HexaBody-CD38 induced CDC, with EC50 values on average 7-fold lower than those of the CD38-targeting mAb daratumumab, which is part of the standard of care for MM. Cytotoxic activity of HexaBody-CD38 showed a positive correlation with CD38 … a digital ltd
CD38 MFI (TIL) - CASI Pharmaceuticals
Tīmeklis2008. gada 1. marts · The morphological and biochemical results including enzymatic activity and proteomic determinations explain the effective nuclear localization of … TīmeklisCD38 density is not sufficient to enable CDC • ISB 1442 induces comparable killing of CD38. high. expressing tumor cells to daratumumab • In NCI-H929 tumor cells, ISB … CD38 protein was purchased from Sino biological (Cat. No: 10818-H08H); Darzalex (Daratumumab) was purchased from Janssen Biotech; Human IgG Isotype control (Cat. No.: 02–7102) and HRP conjugated Goat anti-Human IgG (H + L) Secondary Antibody (Cat. No.: # A18805, dilution for ELISA: 1:2000) FROM … Skatīt vairāk Human embryonic kidney epithelial cells 293 T (ATCC® CRL-3216™), B Lymphocyte Raji (ATCC®CCL-86™) and B Lymphoblast … Skatīt vairāk ELISA plates were coated with antigen (e.g. 2 μg/mL CD38 protein) at 4 °C overnight and then blocked with 1% BSA in PBS containing … Skatīt vairāk Anti-CD38 Antibody 3G3 were generated by immunization of mice with recombinant CD38 protein. After isolation of mouse splenocytes and … Skatīt vairāk ADCC activities of the antibodies were measured by DELFIA EuTDA Cytotoxicity Reagents (Perkin Elmer) according to the manufacturer’s instructions. Briefly, the tumor cells (target … Skatīt vairāk jquery blob ダウンロード